The Missouri State Highway Patrol says a woman from Maryville, Illinois has died and five other people were hurt in a four-vehicle pileup on Interstate 44 in Phelps County.
Troopers say it happened just after 5 p.m. Monday at the 192 eastbound mile marker between Rolla and St. James.
The chain reaction wreck started when one vehicle rear-ended another.
The victim is identified as Jan Fenton, who was 55. She was the driver of the car that was rear-ended, and troopers says her car then rear-ended another vehicle, which flipped over and struck the fourth car.
A passenger in Fenton's vehicle, Lydia Fenton, was airlifted to a hospital in Columbia with serious injuries.
Four others were rushed to the hospital with injuries ranging from minor to serious.